Open access
Sep 2026
Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases
Cheng-Zhang Zhu, Zhi-Yan Zhao, Bo-Jun Song et al.
· bioRxiv · 0 citations
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Jul 2026
Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants
It is revealed that the C-terminal IDR of mammalian ALKBH5 anchors its main activity to mRNA, limiting chromatin engagement in mouse embryonic stem cells, and a conserved role for IDRs in restraining chromatin access by RNA and histone demethylases is uncovered.
Liu-Dan Jiang, Long Zhao, Jiang-Bo Wei et al.
· Nature Genetics · 0 citations