Adjunctive diagnostic utility of POU2F3 in predominantly pulmonary high-grade neuroendocrine carcinomas with limited or discordant conventional marker expression: a case-control study
Background The diagnosis of high-grade neuroendocrine carcinoma may be challenging when conventional neuroendocrine markers show limited or discordant expression. POU2F3 is associated with a neuroendocrine-low subset of small cell carcinoma, but its incremental contribution in routine diagnostic practice remains incomp...