ATF6 contributes to cardiac macrophage polarization and metabolic reprogramming following myocardial ischemia/reperfusion injury.
OBJECTIVE To investigate when and how activating transcription factor 6 (ATF6) contributes to macrophages (Mφ) polarization and tissue repair after myocardial ischemia/reperfusion (I/R) injury. METHODS The WT and ATF6 knockout (ATF6-/-) mice were subjected to myocardial I/R injury. Endoplasmic reticulum stress (ERS)...