Chuan-Qi Yang

Druggable tumor-nerve-immune circuits in cancer pain: model systems, human translatability and therapeutic paradoxes.

Cancer pain is increasingly recognized as an active output of tumor-nerve-immune biology rather than a passive consequence of tissue damage. Tumor-derived algogens, neurotrophic factors, stress signals and immune mediators can sensitize nociceptors, facilitate perineural invasion, remodel myeloid and lymphoid compartme...