Targeted Discovery of Unknown Eremophilane Sesquiterpenes Guided by the Characteristic Post-Modification Colocalization Strategy.
PR-toxin and Sporogen-AO1 have garnered widespread interest, and their structural divergence is attributed to two distinctive sets of tailoring enzymes. Despite recent elucidation of their respective biosynthetic pathways, these two distinctive tailoring cassettes can only operate independently within natural hosts. Ba...