Author

Chuan-Xin Liu

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Open access Sep 2026

Artesunate Targets MBL2 to Modulate the TLR4/NRF2/HO‑1 Axis and Ameliorate Podophyllotoxin‑Induced Liver Injury

Background Drug-induced liver injury (DILI) presents a significant clinical challenge with limited preventive and therapeutic options. Artesunate (ART) holds potential for DILI treatment; however, its precise hepatoprotective mechanisms and direct molecular target(s) remain unclear. Methods We evaluated ART in a podoph...

Ming-Yue Wei, Jun-Jie He, Yan-Zhao Zhang et al. · Drug Design, Development and... · 0 citations

Open access Aug 2026

Molecular Mechanisms of Podophyllotoxin-Induced Subacute Kidney Injury: Oxidative Stress-Mediated Activation of the TRPM2-NOD-NF-κB Pathway.

PT induces subacute kidney injury involving oxidative stress and TRPM2-NOD-NF-κB-related inflammatory signalling and JNJ-28583113 attenuated PPT-induced ROS accumulation, apoptosis, Nod1/Nod2 expression, and NF-κB p65 phosphorylation.

Lulu Chen, Zi-Long Chen, Xin-Ze Li et al. · Environmental Toxicology and... · 0 citations