Open access
Jul 2026
Targeting NAT10 suppresses TFH responses and alleviates allergic asthma via an ac4C-TOX2 axis
Chemical modifications of RNA, such as N4-acetylcytidine (ac⁴C), fine-tune gene expression, but their roles in cell fate determination within the immune system remain poorly understood. Here, we identify the RNA cytidine acetyltransferase NAT10 as a pivotal regulator of T follicular helper (TFH) cell differentiation an...
Zhou-Li Cheng, Zihao Lin, Yilin Ren et al.
· bioRxiv · 0 citations