Immunosenescence, a major hallmark of systemic aging, refers to the progressive functional decline of the immune system. This decline not only compromises host defense and immunological memory but also fuels chronic inflammation and tissue degeneration (collectively known as inflammaging). While single-cell RNA sequenc...
Yu-Hui Zheng, Zeng-Jun Ren, Ya-Fei Yang et al.· Science China Life Sciences· 0 citations
Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin accessibility profiles from regularly exer...
Xue-Mei Song, Jing-Zhi Lv, Si-Liang Ge et al.· Science Advances· 0 citations
A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...
This review examines the experimental and computational foundations of scLR-seq, including platform selection, library design, cell barcode and unique molecular identifier recovery, transcript discovery, and isoform quantification, and summarize emerging insights into isoform usage, alternative splicing, transcription...
