Author

Chuan-Zhong Huang

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Open access Jul 2026

Cross-scale modeling reveals a TFRC-driven immunosuppressive macrophage niche in cervical cancer

A robust five-gene prognostic signature was developed, effectively stratifying patient survival and identifying TFRC as a pivotal metabolic-immune node through which tumor-intrinsic iron metabolism orchestrates an immunosuppressive niche, providing a foundation for novel therapeutic strategies in cervical cancer.

Yusha Chen, Ling Wang, Su-Yu Li et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

Activation of the NF-κB/ALDH1A1 signaling promotes non-mutational resistance to EGFR-TKIs in non-small cell lung cancer

The NF-κB/ALDH1A1 signaling is established as a key non-genetic mechanism of acquired EGFR-TKI resistance and a rational combination strategy to overcome it is provided.

Ling-Yu Zhang, Gui-Bin Weng, Chunjiang Liu et al. · Oncogene · 0 citations

Aug 2026

Cancer-associated fibroblast-derived vascular endothelial growth factor a promotes gastric cancer organoid growth and chemotherapy resistance via paracrine signaling.

A VEGFA-associated functional CAF state promotes gastric cancer organoid growth and chemoresistance through paracrine signaling, highlighting the CAF-VEGFA axis as a potential therapeutic target.

Hongmei Fan, Ling Wang, Chuan-Zhong Huang et al. · Cellular Signalling · 0 citations