3D-Printed DOX-LF-Loaded PLGA Biphasic Composite Scaffold Modulates Macrophage Polarization and Enhances Osteogenic-Angiogenic Regenerative Potential for Periodontitis.
BACKGROUND To develop an immunomodulatory scaffold integrating antibacterial activity with osteogenic-angiogenic coupling for inflammatory periodontal repair. METHODS A biphasic poly(lactic-co-glycolic acid) (PLGA) scaffold incorporating doxycycline-lactoferrin (DOX-LF)-loaded calcium alginate microspheres and fibrob...