This review systematically summarises available advances regarding CVB-D, covering extraction techniques, quantitative analytical methods, pharmacological effects and mechanisms, toxicology, formulation studies, pharmacokinetics, and clinical applications in a coherent manner.
The review proposes a three-step translational framework—patient stratification, target constraint, and cargo matching—and delineates five interlinked clinical development barriers: long-term safety of repeated BBB opening, technical standardization and reproducibility, quantifiable intracerebral PK, biological hit ver...
Chungang Zhang, Deyu Fang, Lin Zhang· Drug Design, Development and...· 0 citations
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