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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Chunhui Cai

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Open access Sep 2026

Pervasive Somatic Mutations in NF1 Drive Cell Type and Spatially Specific Clonal Selection in Neurofibromatosis

Tumorigenesis is a multi-step process shaped by the accumulation of somatic driver mutations, but identifying the earliest steps and cell of origin of tumorigenesis remains challenging. Single cell genomics in >1.7 million single cells across donors with the cancer predisposition syndrome neurofibromatosis type 1 (NF-1...

D. Snellings, Kow Essuman, Benjamin Finander et al. · 0 citations
Open access Aug 2026

Cascading damage to Candida albicans cells through thioredoxin reductase loss

Candida albicans is the most common invasive human fungal pathogen. We show that C. albicans thioredoxin reductase, Trr1, is an attractive antifungal target: it is essential at human body temperature, and fungal and human thioredoxin reductases are structurally divergent, predicting high selectivity of fungal-targeted...

Wanjun Qi, Udita Roy, Chunhui Cai et al. · 0 citations
Open access Aug 2026

Development of a human iPSC and patient phenotyping resource for preclinical investigations of neurodevelopmental disorders.

An integrated collection of genetically defined iPSC lines and associated clinical data provides a powerful platform for investigating disease mechanisms and advancing iPSC-based drug discovery for NDDs.

Ci-Di Chen, Wardiya Afshar-Saber, I. Iglesias et al. · 0 citations

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