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Author

Chun-Hui Liu

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Aug 2026

Chemoenzymatic assembly of structurally defined heparan sulfate oligosaccharides reveals heparanase substrate plasticity and enables inhibitor design.

Heparanase (HPSE) is a promising therapeutic target, yet current heparin-derived inhibitors are limited by structural heterogeneity, poor selectivity, and off-target anticoagulant effects. Here, we synthesized a library of structurally defined heparan sulfate (HS) oligosaccharides via a robust chemoenzymatic strategy,...

Xiao Wang, Qinyu Liu, Guijiao Zhang et al. · 0 citations

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