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Author

Chun-Lan Pu

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2 papers indexed here

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Sep 2026

PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.

Alcohol-associated liver disease (ALD) is driven by oxidative stress, inflammation, hepatocyte death, and intestinal barrier disruption, yet targeted pharmacological options remain limited. Here, we investigated LB23, a proteolysis-targeting chimera designed to degrade poly (ADP-ribose) polymerase 1 (PARP1), in cellula...

Qian-Yuan Gong, Jian-Yu Liu, Hua-Cui Li et al. · 0 citations
Open access Sep 2026

Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling

Background Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapeutic options. Bromodomain-containing protein 4 (BRD4), a BET family epigenetic reader, regulates oncogenic transcription and may represent a pharmacological vulnerability in ESCC. This study evaluated the pharmacologica...

Chun-Lan Pu, Jian-Yu Liu, Heng-Rui Fan et al. · 0 citations

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