Chun-Mao Lin

The estrogen-integrin αvβ3 crosstalk in breast cancer: Modulating PD-L1 and immune evasion.

The mechanisms governing PD-L1 expression in breast cancer are highly complex and context-dependent. This article proposes a novel "dual-track" regulatory model to resolve the conflicting roles of estrogen in tumor immunity. Genomic signaling through ER-α suppresses PD-L1 transcription, explaining lower PD-L1 levels in...