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Author

Chun Pan

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Review Open access Oct 2026

Hemoglobin-based oxygen carriers: evolution, translational applications and clinical considerations

Tissue survival depends on adequate oxygen delivery, yet when red blood cell (RBC) transfusions are unavailable or contraindicated, restoring oxygen delivery remains an urgent clinical need. To meet this need, researchers have developed hemoglobin-based oxygen carriers (HBOCs) that transport oxygen via cell-free hemogl...

Huan Tang, Xin-Yi Liu, Hai Zhang et al. · 0 citations
Open access Oct 2026

PKM2 associated alveolar macrophage remodelling is linked to defective efferocytosis of apoptotic neutrophils in LPS induced acute lung injury.

BACKGROUND Impaired clearance of apoptotic neutrophils by alveolar macrophages (AMs) may sustain inflammation in acute lung injury (ALI). Although PKM2 regulates macrophage inflammatory responses, its relationship with AM efferocytic dysfunction during ALI remains unclear. METHODS We integrated time-course single-cel...

Jun Shen, Fu-Hui Yan, Shao-Kang Yang et al. · 0 citations

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