Maleimide-Thiol Conjugation Enables the Optimization of 68Ga-Labeled CAIX Targeting PET Probes.
Carbonic anhydrase IX (CAIX) is a well-established biomarker of tumor hypoxia and an attractive target for molecular imaging. Despite the development of small-molecule CAIX-targeting positron emission tomography (PET) probes, most exhibit high normal-organ uptake and suboptimal tumor-to-background contrast. Moreover, t...