Dynamic PD-L1 Imaging with a NIR-II Fluorescent Probe for Monitoring and Precision Radio-Immunotherapy in Triple-Negative Breast Cancer
Programmed death-ligand 1 (PD-L1) is a dynamic biomarker relevant to radiotherapy and immunotherapy, motivating the development of noninvasive approaches for longitudinal assessment. Here we report a PD-L1–targeted near-infrared II (NIR-II) fluorescent probe, PNF-ICG, generated by conjugating a cyclic PD-L1–binding p...