Chun-Xiao Mou

N-linked glycosylation of GETV envelope proteins affect viral infection and pathogenicity

ABSTRACT Getah virus (GETV) is an emerging mosquito-borne pathogen with a broad host range, posing a significant threat to livestock and public health. Although putative N-linked glycosylation sites on its envelope proteins have been reported, their precise functional roles remain uncharacterized. In this study, tunica...

SADS-CoV Nsp1 hijacks proteasomal subunits to degrade IRF1.

Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) is an emerging porcine enteric coronavirus that causes severe diarrhea in piglets. Type III interferon (IFN) are crucial for intestinal antiviral defense, and the capacity of SADS-CoV to disrupt IFN-III responses is critical for its replication. This study found that...

Commandeering the controller: The ubiquitin-proteasome tug-of-war between coronavirus and host.