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Open access Sep 2026

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Spinal cord injury (SCI) often causes permanent neurological deficits due to limited neuron regeneration and glial scar formation. Stem cell therapy is promising, but transplanted stem cells often differentiate into astrocytes rather than neurons under inflammatory conditions. To address this, a nuclei‐targeting, his...

Heng Zhou, Qiang Qin, Xi-Qin Li et al. · 0 citations
Sep 2026

ROS‐Responsive Doxorubicin Prodrug‐Manganese Nanoplatform Synergistically Activates cGAS‐STING to Suppress Uveal Melanoma Growth and Metastasis

Tumor‐derived DNA released during chemo‐ or radiotherapy serves as a damage‐associated molecular pattern that activates antitumor immunity through the cGAS‐STING pathway. However, conventional chemotherapy is limited by insufficient tumoricidal efficacy and systemic toxicity, restricting effective activation of inn...

Xiao-Qin Zheng, Ke Yan, Tao Tao et al. · 0 citations

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