Chun-Yan Wang

Resistance mechanisms and reversal strategies of PD-1/PD-L1 inhibitors in melanoma

Programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors have redefined the therapeutic landscape of advanced melanoma, establishing a first-line standard of care that markedly prolongs patient survival. Nevertheless, primary and acquired resistance remain the principal barr...