A smart multi-activatable DNAzyme nanoamplifier for spatiotemporal imaging of multiple piRNAs and on-demand gene therapy.
PIWI-interacting RNAs (piRNAs) are pivotal regulators of physiological and pathological processes, and their aberrant expression is tightly linked to cancer development and prognosis. Nevertheless, their ubiquitous presence in both tumor and normal cells poses a major challenge to achieving cancer-specific detection an...