Author

Chunguang Zhu

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Open access Aug 2026

Computer-Aided Discovery of EGFR G-Quadruplex Targeting Phenanthroimidazole Derivatives Inducing Concurrent Multi-Organelle Damage in Glioblastoma

Compound 3 is established as a uniquely selective EGFR G4 stabilizer, offering a promising multi-organelle-damage strategy for glioblastoma therapy, and triggered DNA damage, mitochondrial oxidative stress, and sequential multi-organelle damage to mitochondria, lysosomes, and the endoplasmic reticulum.

Mengjiao She, Ao Yu, Xiao-Zhan Qiu et al. · Antioxidants · 0 citations

Aug 2026

Discovery of iodo-phenanthroimidazole derivatives as potential HDAC1 inhibitors inducing mitophagy to suppress glioblastoma progression.

The data support a model in which HDAC1 inhibition is associated with mitochondrial dysfunction and mitophagy, contributing to tumor suppression, and highlights the potential of iodo-phenanthroimidazole derivatives as a novel therapeutic strategy for glioblastoma.

Xiao-Mei Shi, Jiangbo Liang, Zhuoyan Wu et al. · Bioorganic chemistry (Print) · 0 citations