Formulation development and characterization of peptide-based spray-forming in situ gel for enhanced buccal permeation and improved stability.
AIM To develop an in situ gelling buccal spray to improve the permeation and stability of reduced glutathione through the buccal mucosa without using ascorbic acid as an antioxidant. MATERIALS AND METHODS Glutathione, a hydrophilic thiol peptide classified as a Biopharmaceutics Classification System (BCS) class III d...