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Author

Claude Libert

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2 papers indexed here

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Open access Sep 2026

Hepatocyte HNF4α Deficiency Protects Against Pneumococcal Sepsis Through a Neutrophil-Dependent Mechanism

Sepsis induces profound alterations in liver function that contribute to disease progression. We previously demonstrated that peritoneal sepsis is associated with marked disruption of hepatic transcriptional programs, including loss-of-function of Hepatocyte Nuclear Factor 4 alpha (HNF4α), a master regulator of hepatic...

J. Vandewalle, Marah Heyerick, S. Timmermans et al. · 0 citations
Open access Jul 2026

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency

The data support a model in which enhancer activation frequency depends on the cumulative function of multiple TFs and is modulated by p300 activity, and the contributions of transcription factor binding and chromatin context are dissected.

Valentina Baderna, Guido Barzaghi, Rozemarijn Kleinendorst et al. · 3 citations

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