Author

Claudia A. Benavente

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Open access Sep 2026

A Meiotic B-type Cyclin Selectively Drives Mitotic Progression and Fidelity in Cancer Cells

Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type cyclin previously thought to function exclusively in female meiosis, is expressed in mitotic cells and interacts with both CDK1 and CDK2. We show that cycl...

Amrutha Kizhedathu, Anh Cao Ngoc Nguyen, Clinton Yu et al. · bioRxiv · 0 citations

Open access Aug 2026

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

Developing novel strategies that can exploit a cell's endogenous machinery to selectively release toxic compounds in diseased cells, while leaving healthy cells unaffected, is a challenging task to accomplish. An established approach involves antigen recognition on tumor cells, enabling targeted delivery of prodrugs in...

Cody A. Loy, Yijun Gu, Samuel C. Kim et al. · Signal Transduction and Targ... · 0 citations