Targeting epithelial IFN-I signaling restores barrier integrity in anti-TNF refractory Crohn’s disease
Abstract Background and Aims Type I interferons (IFN-Is) are central regulators of intestinal epithelial homeostasis, yet their role in driving epithelial dysfunction and therapeutic non-response in Crohn’s disease (CD) remains poorly defined. Here, we investigated epithelial tumor necrosis factor (TNF)–IFN-I crosstalk...