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Author

Claudia D. Spies

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2 papers indexed here

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Open access Oct 2026

rhythmCI: an R package for rhythm detection using harmonic regression amplitude confidence intervals

Background Circadian clocks are evolutionarily conserved systems that orchestrate daily rhythms in human physiology, tissue behavior, and cellular function. In circadian research, the NanoString nCounter platform has emerged as a robust alternative to microarray and RNA sequencing. However, raw instrument output requir...

J. Sreekanth, A. Edel, Claudia D. Spies et al. · 0 citations
Open access Oct 2026

Proteome signatures in ICU patients with COVID-19 and acute brain dysfunction: an observational cohort study

Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational satellite study analysed the proteome signatures...

A. Edel, J. Sreekanth, Florian Kurth et al. · 0 citations

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