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Cláudio José Alves Do Nascimento

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Review Open access Sep 2026

Potassium Channel-Related Developmental and Epileptic Encephalopathies: From Functional Mechanisms to Precision Therapeutics — A Narrative Review Focused on KCNQ2, KCNA2, KCNT1, and KCNB1

Potassium channels are central regulators of neuronal resting membrane potential, action-potential repolarization, firing adaptation, and neurotransmitter release. Pathogenic variants in potassium-channel genes can produce a broad neurodevelopmental spectrum, ranging from self-limited epilepsy to severe developmental a...

Cláudio José Alves Do Nascimento · 0 citations

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