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Author

Claudio Letizia

2 papers indexed here

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Open access Sep 2026

Combined SGLT-2 Inhibitor and Mineralocorticoid Receptor Antagonist Therapy: Effects on the Renin–Angiotensin–Aldosterone System in Heart Failure Treatment

Sodium–glucose cotransporter 2 inhibitors (SGLT2is), originally developed as glucose-lowering agents for type 2 diabetes mellitus, have increasingly demonstrated clinical benefits in patients with chronic kidney disease and heart failure. We retrospectively evaluated 114 patients with heart failure admitted to the Emer...

L. Petramala, Luca Caprioni Grasso, Giuseppe Calise et al. · 0 citations
Open access Oct 2026

The Interplay Between Klotho, Aldosterone, and Vascular Damage in Chronic Kidney Disease: Insights from a Cross-Sectional Study.

BACKGROUND Patients with chronic kidney disease (CKD) are at increased risk of vascular calcification and cardiovascular mortality. Reduced Klotho levels have been associated with vascular damage in CKD through both direct and indirect mechanisms. Klotho deficiency, a hallmark of CKD, has been suggested to contribute t...

L. Tartaglione, S. Rotondi, M. Pasquali et al. · 0 citations

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