Author

Clayton E. Mathews

3 papers indexed here

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Open access Sep 2026

Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background

Summary Genome-wide association studies have identified IFIH1, which encodes the double-stranded RNA sensor MDA5, as a type 1 diabetes (T1D) risk locus. The IFIH1 E627∗ variant is associated with protection from T1D, whereas A946T is associated with increased risk. To examine how these variants influence islet response...

Daniel A. Veronese-Paniagua, Cameron Banks, Kameron Bradley et al. · iScience · 0 citations

Open access Aug 2026

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

These studies identified novel mechanisms of β-cell dysregulation before symptomatic onset and independent of T-cell infiltration in T1D pathogenesis.

Alexandra E. Cuaycal, Elizabeth A. Butterworth, Scott E. Stimpson et al. · bioRxiv · 0 citations

Review Jul 2026

Targeting MDA5-Mediated Interferon Responses in Type 1 Diabetes: Structural Insights, Mechanism, and Potential Therapeutic Approaches.

Melanoma differentiation-associated protein 5 (MDA5), encoded by IFIH1, is a cytosolic double-stranded RNA (dsRNA) sensor. Mutation of IFIH1 resulting in MDA5 deficiency causes immune dysfunction and predisposition to specific respiratory viral pathogens due to the inability of innate immune system to detect viral dsRN...

Opeoluwa Iwaloye, Clayton E. Mathews, Danmeng Li · Journal of Interferon and Cy... · 0 citations