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Author

Cody A. Loy

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Open access Aug 2026

From probe to prodrug: immunoproteasome activity as a trigger for disease-selective therapeutics

Developing novel strategies that can exploit a cell's endogenous machinery to selectively release toxic compounds in diseased cells, while leaving healthy cells unaffected, is a challenging task to accomplish. An established approach involves antigen recognition on tumor cells, enabling targeted delivery of prodrugs in...

Cody A. Loy, Yijun Gu, Samuel C. Kim et al. · 0 citations
Open access Jul 2026

Two Mechanisms One Molecule: Developing a ‘Truly’ Bifunctional Degrader Targeting Rpn13 and CRBN

Truly-4 is the first noncovalent small molecule shown to degrade full-length Rpn13, a target previously approached using covalent or domain-restricted strategies, and establishes a generalizable framework for engineering bifunctional degraders that program the proteasome to execute parallel degradation mechanisms and h...

Cody A. Loy, Shawn E Vinogradsky, Darci J. Trader · 0 citations

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