Open access
Sep 2026
High-order enhancer hubs buffer allelic regulatory variation through kinetic compensation
Diploid genomes carry millions of heterozygous variants in cis-regulatory DNA, yet most genes produce similar RNA output from two parental alleles. How this balance is maintained is unclear. We developed Nanopore-HiChIP, a long-read method that maps high-order enhancer hubs on each haplotype. Over half of these enhance...
Jiang Tan, M. Sentmanat, Yu-Qing Wu et al.
· bioRxiv · 0 citations