Open access
Sep 2026
Dynamic chromatin tethering of MDC1 regulates genome stability
It is demonstrated that the proline-serine-threonine repeat region of Mediator of DNA Damage Checkpoint 1 (MDC1) is a multivalent nucleosome-binding domain, sufficient to tether chromatin in multiple contexts, and maintains genome stability during mitosis.
Joshua R. Heyza, Mariia Mikhova, Cody Phillips et al.
· Nucleic Acids Research · 0 citations