Author

Colby F. Lewallen

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Review Open access Sep 2026

The Biology and Cell Engineering of Retinal Pigment Epithelium Cell Transplantation: Developing a Living Drug.

Age-related macular degeneration (AMD) is a multifactorial retinal disease that causes progressive vision loss, with retinal pigment epithelium (RPE) atrophy representing a key initiating event. The RPE monolayer plays a crucial role in maintaining photoreceptor and choriocapillaris health and function. In advanced AMD...

Sudipta Mahato, Elena Daniele, Colby F. Lewallen et al. · Annual Review of Vision Scie... · 0 citations

Open access Aug 2026

Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.

This study develops induced pluripotent stem cell-derived RPE models (iRPE) and identifies two drugs, pioglitazone, a mitochondrial metabolic modulator, and galunisertib, a TGFBR1 inhibitor, as potential therapeutic candidates for multiple ciliopathy subtypes.

Dominik Reichert, Sena Gul, D. Ortolan et al. · Cell Reports · 0 citations