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Author

Cole W. Christopher

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2 papers indexed here

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Open access Oct 2026

Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming

Despite the success of immune checkpoint blockade in cancer therapy, overcoming the immunosuppressive tumor microenvironment remains a major barrier to durable responses. Here, we introduce cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4)-targeting chimeras (cTACs), a class of synthetic molecules that harness CTLA-...

Ping Ren, Shao-Yu Fang, Shu-Shu Zhao et al. · 0 citations
Review Open access Jul 2026

In vivo CRISPR editing for cancer immunotherapy

This review summarizes recent progress in applying CRISPR systems in vivo for cancer immunotherapy, focusing on approaches that target cancer cells and the tumor microenvironment, as well as those that directly engineer immune cell populations themselves.

Cole W. Christopher, Xiaoyu Zhou · 0 citations

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