Author

Colin Farrell

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Open access Sep 2026

68 LNK001 is a High-Fidelity AND-Logic-Gated CAR T Cell Therapy that Enables Precision Targeting of Clear Cell Renal Cell Carcinoma (ccRCC): Target Discovery and Validation for the ATHENA Phase 1 Trial

Abstract Background Chimeric antigen receptor (CAR) T cell immunotherapies have shown exciting clinical benefits in hematologic malignancies, whereas challenges have persisted in addressing solid tumors. A key reason for the lack of success in solid tumors is on-target off-tumor (OTOT) toxicity that has previously occu...

Alexander J. Bankovich, Bryan A. Smith, Colin Farrell et al. · The Oncologist · 0 citations

Open access Sep 2026

83 Preclinical Evaluation of LNK001: Stringent AND-Gate Fidelity and Potent Efficacy of a Dual-Antigen CAIX/ENPP3 CAR T Cell Therapy for Clear Cell Renal Cell Carcinoma

The Logic-gated INtracellular networK (LINK) platform, a Boolean AND-gate architecture in which two synthetic receptors are coupled to distinct proximal T cell signaling adapters, is developed, and LNK001, the first clinical candidate from the LINK platform, is the first clinical candidate from the LINK platform.

M. Wallet, R. Larson, Yogin Patel et al. · The Oncologist · 0 citations