Author

Colin G. Nichols

2 papers indexed here

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Open access Sep 2026

MgATP/MgADP-dependent conformational dynamics and intrinsically disordered regions of vascular K ATP channels revealed by cryoEM

Vascular smooth muscle KATP channels, composed of the pore-forming Kir6.1 and regulatory SUR2B subunits, control vascular tone, dysfunction of which causes systemic disease. Vascular KATP is regulated by Mg-nucleotides, but the underlying structural mechanism has remained elusive. Here, we determined cryoEM structures...

C. M. Driggers, Yi-Ying Kuo, Zhong-Ying Yang et al. · bioRxiv · 0 citations

Oct 2026

Multiple ABCC8 Loss-of-Function Mutations Associated with Paradoxical Maturity-Onset Diabetes of the Young.

ARTICLE HIGHLIGHTS The effects of 16 ABCC8 variants, previously reported in heterozygous association with maturity-onset diabetes of the young (MODY), some with prior diagnosis of hypersinulinism, were assessed in recombinant Kir6.2/SUR1 KATP channels. Thirteen of 16 variants cause loss-of-function, 3 of 16 have no eff...

Rosa Scala, Hao Zhang, Jian Gao et al. · Diabetes · 0 citations