Conceição Bettencourt

White matter dysfunction in Alzheimer’s disease: a convergence or divergence of hypotheses

Alzheimer’s disease (AD) is a multifactorial disease with several key hypotheses centred around its pathological hallmarks, including amyloid and tau and other mechanisms, such as vascular dysfunction. Revised criteria for AD diagnosis reflects these hypotheses and includes white matter hyperintensities (WMH) as a bi...