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Concepción Alonso

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Open access Sep 2026

Exploring phosphorus substitution in chromeno[4,3-d]pyrido[1,2-a]pyrimidines: new insights into Topoisomerase 1 inhibition and cytotoxicity.

Phosphorylated chromeno[4,3-d]pyrido[1,2-a]pyrimidines were synthesized from functionalized 2-aminopyridines and evaluated as novel inhibitors of human DNA topoisomerase 1. Several compounds demonstrated potent enzymatic inhibition, and notable derivatives such as 8b and 10a exhibited selective antiproliferative activi...

Leyre Lopez-Aguileta, B. Knudsen, C. Tesauro et al. · 0 citations

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