Open access
Aug 2026
Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α‑Synuclein Phase Separation
The Parkinson’s disease-related protein α-synuclein can form solid amyloid fibrils through liquid–liquid phase separation (LLPS) and liquid-to-solid phase transition. The most deleterious familial mutation E46K has recently been shown to enhance α-synuclein LLPS and subsequent solidification; yet, the precise mechanism...
Zhong-Yuan Yang, Yi-Ming Tang, Jitao Wen et al.
· JACS Au · 0 citations