Author

Cong-Xin Li

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Open access Aug 2026

Protective Effect of the NHE1 Inhibitor Buthutin A on Oxidative Stress-Induced Apoptosis in HUVECs

Objective: Na+/H+-exchanger 1 (NHE1) inhibitors are considered promising drugs for cardiovascular diseases. Buthutin A (Buth A) is a novel NHE1 inhibitor that was reported by our team recently. In this research, we explored the protective effect of Buth A against angiotensin II (AngII)-induced injury in vitro and in vi...

Chen-Yue Shao, Xin-Ru Zhao, Zhi-Ling Cheng et al. · ACS Omega · 0 citations

Open access Sep 2026

SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload

Background Tyrosine kinase inhibitors (TKIs) are potent anticancer agents; however, their clinical application is often restricted because of cardiotoxic effects. The mechanisms underlying cardiotoxicity that are shared across different TKIs remain inadequately understood. Purpose This study aimed to investigate the ro...

Mei-Ling Gao, Zhe Wang, Zhi-Ling Cheng et al. · Frontiers in Pharmacology · 0 citations