Open access
Sep 2026
Targeted Nanoparticles for PROTAC-Mediated JAK1/JAK2 Degradation for Bladder Cancer Treatment
PPcJ achieved near-plateau cellular uptake at low concentrations and partially evaded lysosomal degradation, which significantly induced apoptosis in bladder cancer cells and suppressed key components of the JAK/STAT signaling pathway.
Wei-Hong Ding, Xin-Yue Zhang, Hong-Dan Wu et al.
· International Journal of Nan... · 0 citations