Author

Connor P. Frasier

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Review Jul 2026

Abstract B011: Single-molecule protein footprinting with Fiber-seq resolves coordinated chromatin states across regulatory domain

An integrated single-molecule view of regulatory remodeling may support identification of adaptive resistance mechanisms, compensatory regulatory programs, pharmacodynamic biomarkers, and candidate synthetic lethal interactions relevant to epigenetic drug development.

Keith E. Maier, James T. Anderson, Connor P. Frasier et al. · Clinical Cancer Research · 0 citations

Open access Jul 2026

Unraveling genomic regulatory complexity by adding chromatin accessibility to the long-read sequencing toolkit 2247245

Fiber-seq simultaneously profiles chromatin accessibility, DNA methylation, protein footprints, and genetic variation on single molecules at near—base-pair resolution, revealing how genetic and epigenetic features interact to regulate gene expression and provides a powerful new framework for dissecting immune cell func...

Emily A. Madden, James T. Anderson, M. Cowles et al. · Journal of Immunology · 0 citations