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Constance Alabert

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Open access Oct 2026

Dual Role of Cx43 in Enhancing CDK4/6 Inhibitor Response and Promoting the Elimination of Therapy-Induced Senescent Tumor Cells

Breast cancer has become the most prevalent malignancy worldwide. A key clinical advance has been the introduction of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i), that in combination with endocrine therapy has been a major advance for the treatment of luminal (ER⁺/HER2⁻) breast cancer. CDK4/6i induce cell cycle ar...

P. Carpintero-Fernández, Marta Barturen-Gómez, Vanesa Alvarez et al. · 0 citations
Open access Oct 2026

RIF1 coordinates the stepwise post-replicative H3K9me3 recovery.

DNA replication dilutes parental histones and their post-translational modifications, requiring restoration of epigenetic marks on newly incorporated histones. H3K9me3 restoration is unusually slow, extending into the following G1 phase, but the mechanisms governing this delay remain unclear. Here, we show that RIF1 re...

Nai-Ming Chen, S. Bandau, Reshma Ravindran Nair et al. · 0 citations

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