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Author

Consuelo Sauceda

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Open access Oct 2026

Integrative multi-omics reveals CUL4B as a modulator of macrophage pyroptosis and innate defense against Staphylococcus aureus.

Staphylococcus aureus (SA) causes a broad range of invasive human diseases, increasingly complicated by antibiotic resistance. Macrophages (MΦ) play a central role in innate immunity, yet key aspects of their interaction with SA remain incompletely understood because of the pathogen's diverse immune evasion strategies....

Fatemeh Askarian, Daniel Sun, Jasmine Tat et al. · 0 citations
Open access Aug 2026

Fibroblasts resist Staphylococcus aureus on the skin surface by responding to interleukin-1 and recruiting neutrophils

It is found that fibroblast recognition of interleukin-1 is essential for immune response and fibroblasts actively participate in innate immunity and highlight an IL-1R1–dependent keratinocyte-fibroblast-neutrophil axis of communication.

Jared Simmons, T. Nakatsuji, Feng-Wu Li et al. · 0 citations

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