Open access
Aug 2026
The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis
Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralization remain unclear. Here, we study the parasite’s H...
Louis Sarrazin, Melissa R. Rosenthal, J. Kloehn et al.
· Nature Communications · 0 citations