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It is demonstrated that while blocking β2-ARs is sufficient to reduce NE-driven osteoclastogenesis, excessive NE does not fully explain SCI-induced bone loss.
INTRODUCTION Chronic kidney disease (CKD) has devastating effects on the skeletal system resulting in an increased fracture risk. CKD results in the buildup of metabolites in the blood (often referred to as uremic toxins), and several uremic toxins have been linked to adverse skeletal outcomes. We have shown that dieta...
Chronic kidney disease (CKD) leads to significant bone loss and high risk of fractures. Fractures are even more prevalent in the aging population with CKD. Cortical bone is particularly impacted in CKD due to cortical thinning and the development of cortical porosity. The goal of this study was to assess the impact of...
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