Author

Courtney D. DiNardo

2 papers indexed here

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Aug 2026

A quantitative definition of the clinical manifestations of GATA2 deficiency in adults.

Germline GATA2 deficiency is a pleiotropic condition 1-8 characterized by numerous phenotypes, including monocytopenia, immunodeficiency, microbial susceptibilities, and high rates of myeloid malignancies 1,8. Accurate curation of germline GATA2 variants is critical for patient care and requires well-defined phenotypes...

S. Mohan, Tilda E Carlelycke, Ashwin L Koppayi et al. · Blood · 0 citations

Jul 2026

LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models.

Acute myeloid leukemia (AML) is an aggressive blood disorder characterized by rapid growth of poorly differentiated myeloid cells. Gain-of-function mutations in isocitrate dehydrogenases (IDHs) are detected in ~20% of AML and ~80% of secondary gliomas. Mutant IDH1/2 isoenzymes acquire neomorphic activity to produce 2-h...

Nathan A Brooks, Anna Skwarska, V. Salama et al. · Blood Cancer Discovery · 0 citations