Open access
Jul 2026
Crosstalk Between Donor T Cells and Recipient IL-33+ Target Tissue Stroma Controls Alloimmune Responses Causing Graft-versus-Host Disease 2260079
Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic cell transplantation (AlloHCT) and mechanisms releasing IL-33 from nuclear sequestration remain elusive, but free IL-33 directly activates donor CD4+ T cells to promote Th1 differentiation and expansion.
G. Dwyer, L. Mathews, Bailey T. Chalmers et al.
· Journal of Immunology · 0 citations